Thymosin Alpha-1 10mg

Description

Thymosin alpha-1 (Tα1) is a 28-amino-acid peptide, acetylated at its N-terminus, first isolated from thymosin fraction 5 — a calf thymus extract — by Allan Goldstein and colleagues in 1977. It corresponds to the N-terminal region of prothymosin alpha, a protein expressed in many tissues.

Tα1 is studied as an immunomodulatory peptide. In cell and animal models it has been reported to influence T-cell maturation and differentiation, the activation of dendritic cells through Toll-like receptor (TLR) signalling, and the balance of cytokines associated with Th1-type responses. Much of the literature examines how this thymus-derived peptide shapes innate and adaptive immune responses under experimental conditions.

Published research areas include infection and host-response models, vaccine-response (adjuvant) studies, immune ageing (immunosenescence) and tumour immunology. These findings describe research settings; they are not claims about this product, which is supplied only as a reference material for laboratory research.

Despite the similar name, thymosin alpha-1 is unrelated to thymosin beta-4, the protein that TB-500 reproduces. The two differ in sequence, size and biological role: Tα1 is studied mainly in immunology, while thymosin beta-4 is studied mainly for actin binding and tissue-repair models.

Pepspan's Thymosin Alpha-1 is supplied as a white lyophilized powder, 10mg per vial, with a purity specification of ≥98% by HPLC. The first lot will be analysed by an independent laboratory and the certificate will be published on its lot page.

Handling & Storage

Thymosin Alpha-1 is supplied lyophilized; for laboratory work it is dissolved in a suitable sterile aqueous solvent under aseptic conditions — swirl gently, do not shake.

• Expected appearance: Clear, colourless, particulate-free solution.
• After reconstitution: Store at 2-8°C protected from light. Prepare aliquots to avoid repeated freeze-thaw cycles.

Composition

• Peptide: Thymosin alpha-1 (Tα1)
• Sequence: Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH
• Length: 28 amino acids, N-terminal acetylation
• Molecular Formula: C129H215N33O55
• Molecular Weight: ≈3108.3 g/mol
• Purity: ≥98% (HPLC, specification)
• Appearance: White lyophilized powder
• Quantity: 10mg per vial

Storage

• Store the lyophilized peptide at -20°C for long-term storage.
• For short-term storage, refrigerate at 2-8°C.
• After reconstitution, store at 2-8°C protected from light.
• Avoid repeated freeze-thaw cycles.
• Protect from light and moisture at all times.

Certificate of Analysis

The first lot of Thymosin Alpha-1 sold by Pepspan will be analysed by an independent laboratory for HPLC purity and the actual content per vial. The certificate will be published on the lot page, and every later lot will be tested the same way.

Current batch: PEP-TA1-2610-01 · lot page →

Every lot of Thymosin Alpha-1 will be tested by an independent laboratory: HPLC purity and the actual content per vial. Reports are lot-specific — not generic.

Research Disclaimer

This product is intended for laboratory research use only. It is not a drug, food, cosmetic, or dietary supplement. Pepspan's Thymosin Alpha-1 is not approved for human or veterinary use by any regulatory agency in the EU or US. It must not be administered to humans or animals outside of approved clinical trials. By purchasing this product, you confirm that you are a qualified researcher and that this product will be used exclusively for legitimate scientific research purposes. Pepspan assumes no liability for any misuse of this product. All handling must comply with local regulations and institutional safety protocols.

Frequently Asked Questions

What is Thymosin Alpha-1?

Thymosin alpha-1 (Tα1) is a 28-amino-acid, N-terminally acetylated peptide first isolated from a thymus extract (thymosin fraction 5) in 1977. It corresponds to the N-terminal region of prothymosin alpha. It is studied in immunology research for its effects on T-cell and dendritic-cell function in cell and animal models.

Is Thymosin Alpha-1 the same as TB-500?

No. TB-500 is full-length thymosin beta-4 (43 amino acids), a different protein. Thymosin alpha-1 and thymosin beta-4 share part of their name because both were first described in thymus extracts, but they differ in sequence, size and biological role: Tα1 is studied mainly in immunology, thymosin beta-4 mainly for actin binding and tissue-repair models.

What research areas cite Thymosin Alpha-1?

Published research on thymosin alpha-1 covers T-cell maturation and differentiation, dendritic-cell activation through Toll-like receptor signalling, cytokine balance, infection and host-response models, vaccine-response (adjuvant) studies, immune ageing and tumour immunology. Researchers should consult the primary literature for the models and conditions reported in each study.

How should Thymosin Alpha-1 be stored?

Store the lyophilized vial at -20°C for long-term storage, or at 2-8°C for short periods, protected from light and moisture. After reconstitution under aseptic laboratory conditions, keep the solution at 2-8°C protected from light and avoid repeated freeze-thaw cycles.

Is Thymosin Alpha-1 available at Pepspan?

Yes. Thymosin Alpha-1 is in stock and ships from Spain. Its independent analysis is scheduled and will be published on the lot page.

Do I need a prescription for Thymosin Alpha-1?

Pepspan does not sell medicines and does not dispense against prescriptions. Thymosin Alpha-1 is supplied exclusively as a reference material for laboratory research, not for human or veterinary use. Check the regulations in your country before ordering.

Where can I buy Thymosin Alpha-1 in Europe?

Pepspan supplies Thymosin Alpha-1 10mg lyophilized vials from its stock in Spain, with tracked delivery in the EU in 2–5 business days and free EU shipping on orders from €50. Research use only.

Further Research Resources

Additional research articles, comparison guides, and laboratory protocols related to this product:

• How to store research peptides
• How to verify a Certificate of Analysis