5-Amino-1MQ 50mg
50mg per vial — Lyophilized Powder
Coming soon — use the Notify me button to get an email as soon as the first lot is in stock.
Description
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule research compound — not a peptide — developed as a selective, membrane-permeable inhibitor of nicotinamide N-methyltransferase (NNMT). NNMT is a cytosolic enzyme that transfers a methyl group from S-adenosylmethionine (SAM) to nicotinamide, producing 1-methylnicotinamide.
Because nicotinamide is a precursor in the NAD+ salvage pathway and SAM is the cell's main methyl donor, NNMT sits at the junction of NAD+ metabolism and cellular methylation. NNMT expression is elevated in the adipose tissue of obesity models, which made the enzyme a target for metabolic research.
In published work from the University of Texas Medical Branch (Neelakantan et al., Biochemical Pharmacology, 2018), 5-amino-1MQ lowered 1-methylnicotinamide and raised intracellular NAD+ and SAM levels in cultured adipocytes, and treating diet-induced obese mice with the compound was associated with lower body weight and white adipose tissue mass. A later study by the same group (2019) examined NNMT inhibition with 5-amino-1MQ in mouse models of aged skeletal-muscle regeneration. These are preclinical findings in animal and cell models; they have not been demonstrated in humans.
Pepspan's 5-Amino-1MQ is supplied as a lyophilized solid, 50mg per vial, with a purity specification of ≥98% by HPLC. The first lot will be analysed by an independent laboratory and the certificate will be published on its lot page.
Handling & Storage
5-Amino-1MQ is supplied lyophilized. It is water-soluble; stock solutions for laboratory work are prepared under aseptic conditions.
- Stock solutions: Store at 2-8°C protected from light for short periods, or aliquot and freeze to avoid repeated freeze-thaw cycles.
- Salt form: The salt form (typically iodide) and exact content are stated on the lot's certificate of analysis.
Composition
- Compound: 5-Amino-1-methylquinolinium (small molecule, quaternary quinolinium)
- Target: Nicotinamide N-methyltransferase (NNMT) inhibitor
- Molecular Formula: C10H11N2+ (cation); C10H11IN2 as the iodide salt
- Molecular Weight: 159.21 g/mol (cation); 286.11 g/mol (iodide salt)
- Purity: ≥98% (HPLC, specification)
- Form: Lyophilized solid
- Quantity: 50mg per vial
Storage
- Store the sealed vial at -20°C for long-term storage.
- For short-term storage, keep at 2-8°C.
- Keep stock solutions at 2-8°C protected from light, or aliquot and freeze.
- Avoid repeated freeze-thaw cycles.
- Protect from light and moisture at all times.
Certificate of Analysis
The first lot of 5-Amino-1MQ sold by Pepspan will be analysed by an independent laboratory for HPLC purity and the actual content per vial. The certificate will be published on the lot page, and every later lot will be tested the same way.
Batch Purity Report
Independent lab — pendingCurrent Batch: first lot pending
Every lot of 5-Amino-1MQ will be tested by an independent laboratory: HPLC purity and the actual content per vial. Reports are lot-specific — not generic.
View All Purity Reports →Research Disclaimer
This product is intended for laboratory research use only. It is not a drug, food, cosmetic, or dietary supplement. 5-Amino-1MQ is not approved for human or veterinary use by any regulatory agency in the EU or US. It must not be administered to humans or animals outside of approved clinical trials. By purchasing this product, you confirm that you are a qualified researcher and that this product will be used exclusively for legitimate scientific research purposes. Pepspan assumes no liability for any misuse of this product. All handling must comply with local regulations and institutional safety protocols.
Frequently Asked Questions
What is 5-Amino-1MQ?
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), the enzyme that methylates nicotinamide using S-adenosylmethionine. It was developed as a selective, membrane-permeable NNMT inhibitor for metabolic research.
Is 5-Amino-1MQ a peptide?
No. 5-Amino-1MQ is a small quaternary quinolinium molecule, not a peptide. It is supplied in a vial like the peptides in our catalogue, but its chemistry, size and handling are those of a small-molecule compound.
How does 5-Amino-1MQ relate to NAD+?
NNMT consumes nicotinamide, a precursor in the NAD+ salvage pathway, and S-adenosylmethionine, the main methyl donor. In cultured adipocytes, inhibiting NNMT with 5-amino-1MQ has been associated with higher intracellular NAD+ and SAM levels. This is why the compound is studied alongside NAD+ metabolism research.
What research cites 5-Amino-1MQ?
The main published work comes from the University of Texas Medical Branch: a 2018 study in diet-induced obese mice (Biochemical Pharmacology) and a 2019 study on NNMT inhibition in models of aged skeletal-muscle regeneration. These are preclinical studies in animal and cell models; researchers should consult the primary literature for the models and conditions reported.
How should 5-Amino-1MQ be stored?
Store the sealed vial at -20°C for long-term storage, or at 2-8°C for short periods, protected from light and moisture. Keep stock solutions at 2-8°C protected from light, or aliquot and freeze to avoid repeated freeze-thaw cycles.
When will 5-Amino-1MQ be available at Pepspan?
5-Amino-1MQ is coming soon. Use the Notify me button on this page to receive an email as soon as the first lot is in stock; its independent analysis will be published on the lot page.
Do I need a prescription for 5-Amino-1MQ?
Pepspan does not sell medicines and does not dispense against prescriptions. 5-Amino-1MQ is supplied exclusively as a reference material for laboratory research, not for human or veterinary use. Check the regulations in your country before ordering.
Where can I buy 5-Amino-1MQ in Europe?
Pepspan will supply 5-Amino-1MQ 50mg vials from its stock in Spain, with tracked delivery in the EU in 2–5 business days and free EU shipping on orders from €50. It is not in stock yet: leave your email with the Notify me button and you will be told as soon as it is available. Research use only.
Further Research Resources
Additional research articles, comparison guides, and laboratory protocols related to this product:
