Kisspeptin-10 10mg

Description

Kisspeptin-10 is the C-terminal decapeptide of kisspeptin, corresponding to the human sequence Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 (residues 45-54 of kisspeptin-54, also called metastin). It is the shortest fragment of the KISS1 gene product reported to retain full activity at its receptor.

The peptide acts as an agonist of the KISS1 receptor (KISS1R), also known as GPR54, a G-protein-coupled receptor. Its C-terminal Arg-Phe-NH2 motif places kisspeptin in the RF-amide peptide family, and structure-activity studies identify Phe6, Arg9 and the amidated C-terminal Phe10 as critical for receptor binding and activation.

Kisspeptin-10 is widely used as a reference agonist in KISS1 receptor pharmacology. Published research in cell and animal models examines receptor binding and distribution (the receptor is expressed in the hypothalamus and in several peripheral tissues), the intracellular signalling that follows receptor activation (Gq/11-coupled phospholipase C signalling and calcium mobilisation) and structure-activity relationships of kisspeptin analogues.

These findings describe research settings; they are not claims about this product, which is supplied only as a reference material for laboratory research.

Pepspan's Kisspeptin-10 is supplied as a white lyophilized powder, 10mg per vial, with a purity specification of ≥98% by HPLC. The first lot will be analysed by an independent laboratory and the certificate will be published on its lot page.

Handling & Storage

Kisspeptin-10 is supplied lyophilized; for laboratory work it is dissolved in a suitable sterile aqueous solvent under aseptic conditions — swirl gently, do not shake.

• Expected appearance: Clear, colourless, particulate-free solution.
• After reconstitution: Store at 2-8°C protected from light. Prepare aliquots to avoid repeated freeze-thaw cycles.

Composition

• Peptide: Kisspeptin-10 (KP-10)
• Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 (human)
• Length: 10 amino acids (decapeptide), C-terminal amidation
• Molecular Formula: C63H83N17O14
• Molecular Weight: 1302.4 g/mol
• Purity: ≥98% (HPLC, specification)
• Appearance: White lyophilized powder
• Quantity: 10mg per vial

Storage

• Store the lyophilized peptide at -20°C for long-term storage.
• For short-term storage, refrigerate at 2-8°C.
• After reconstitution, store at 2-8°C protected from light.
• Avoid repeated freeze-thaw cycles.
• Protect from light and moisture at all times.

Certificate of Analysis

The first lot of Kisspeptin-10 sold by Pepspan will be analysed by an independent laboratory for HPLC purity and the actual content per vial. The certificate will be published on the lot page, and every later lot will be tested the same way.

Current Batch: awaiting first delivery

Every lot of Kisspeptin-10 will be tested by an independent laboratory: HPLC purity and the actual content per vial. Reports are lot-specific — not generic.

View All Purity Reports →

Research Disclaimer

This product is intended for laboratory research use only. It is not a drug, food, cosmetic, or dietary supplement. Pepspan's Kisspeptin-10 is not approved for human or veterinary use by any regulatory agency in the EU or US. It must not be administered to humans or animals outside of approved clinical trials. By purchasing this product, you confirm that you are a qualified researcher and that this product will be used exclusively for legitimate scientific research purposes. Pepspan assumes no liability for any misuse of this product. All handling must comply with local regulations and institutional safety protocols.

Frequently Asked Questions

What is Kisspeptin-10?

Kisspeptin-10 is the C-terminal decapeptide of kisspeptin, human sequence Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2. It is an agonist of the KISS1 receptor (GPR54), studied in neuroendocrinology research.

What does Kisspeptin-10 bind to?

Kisspeptin-10 acts as an agonist at the KISS1 receptor (GPR54), a G-protein-coupled receptor. Structure-activity studies identify residues in its C-terminal region as critical for receptor binding and activation — notably Phe6, Arg9 and the amidated Phe10 of the Arg-Phe-NH2 (RF-amide) motif that Kisspeptin-10 shares with other RF-amide peptides.

What research areas cite Kisspeptin-10?

Published research on Kisspeptin-10 covers KISS1 receptor pharmacology in cell and animal models: receptor binding and distribution, the intracellular signalling that follows receptor activation (Gq/11-coupled phospholipase C and calcium signalling) and structure-activity studies of kisspeptin analogues. Researchers should consult the primary literature for the models and conditions reported in each study.

How should Kisspeptin-10 be stored?

Store the lyophilized vial at -20°C for long-term storage, or at 2-8°C for short periods, protected from light and moisture. After reconstitution under aseptic laboratory conditions, keep the solution at 2-8°C protected from light and avoid repeated freeze-thaw cycles.

When will Kisspeptin-10 be available at Pepspan?

Kisspeptin-10 is coming soon. Use the Notify me button on this page to receive an email as soon as the first lot is in stock; its independent analysis will be published on the lot page.

Do I need a prescription for Kisspeptin-10?

Pepspan does not sell medicines and does not dispense against prescriptions. Kisspeptin-10 is supplied exclusively as a reference material for laboratory research, not for human or veterinary use. Rules for research peptides differ by country; check your local regulations before ordering.

Where can I buy Kisspeptin-10 in Europe?

Pepspan will supply Kisspeptin-10 10mg lyophilized vials from its stock in Spain, with tracked delivery in 1–3 business days in Spain, 3–5 in Germany, and usually 2–5 across the rest of the EU, plus free shipping on orders from €50. It is not in stock yet: leave your email with the Notify me button and you will be told as soon as it is available. Research use only.

Further Research Resources

Additional research articles, comparison guides, and laboratory protocols related to this product:

• How to store research peptides
• How to verify a Certificate of Analysis