MOTS-c 10mg

Description

MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA type-c) is a mitochondrial-derived peptide (MDP) consisting of 16 amino acids encoded within the mitochondrial genome. First identified in 2015 by Dr. Changhan David Lee and colleagues at the University of Southern California, MOTS-c represents a groundbreaking discovery in mitochondrial biology — demonstrating that mitochondria produce signaling peptides that regulate nuclear gene expression, a phenomenon termed "retrograde signaling" or mitonuclear communication.

The primary mechanism of MOTS-c action involves activation of the AMPK (AMP-activated protein kinase) pathway, the master cellular energy sensor. In landmark studies published in Cell Metabolism, MOTS-c was shown to activate AMPK signaling in skeletal muscle, enhancing glucose uptake and fatty acid oxidation independently of insulin. Treatment with MOTS-c prevented diet-induced obesity in mice, improved glucose tolerance, and increased insulin sensitivity. Remarkably, these metabolic effects were observed both with systemic administration and with direct treatment of muscle cells in culture.

Research into MOTS-c and exercise biology has produced particularly compelling findings. Circulating MOTS-c levels increase significantly during exercise in humans, and MOTS-c has been shown to translocate to the nucleus in response to metabolic stress, where it directly regulates the expression of genes involved in glucose metabolism and antioxidant defense. In aged mice, MOTS-c treatment improved physical performance on treadmill tests, enhanced exercise capacity, and reduced markers of cellular senescence in skeletal muscle.

The longevity implications of MOTS-c are supported by population genetics data. Studies have identified a specific MOTS-c variant (m.1382A>C, K14Q) that is significantly enriched in Japanese centenarians compared to the general population. This variant appears to enhance MOTS-c signaling activity, suggesting that naturally elevated MOTS-c function may contribute to exceptional longevity. Additional research has shown that circulating MOTS-c levels decline with age in humans, paralleling the age-related decline in mitochondrial function.

Beyond metabolic regulation, MOTS-c has demonstrated cytoprotective properties in models of oxidative stress, inflammation, and cellular senescence. The peptide has been shown to reduce inflammatory cytokine production, protect against endothelial dysfunction, and improve bone density in osteoporosis models. MOTS-c is supplied as a white lyophilized powder at 10mg per vial, exceeding 98% purity by HPLC analysis.

Composition

• Peptide: MOTS-c (Mitochondrial ORF of 12S rRNA type-c)
• Sequence: MRWQEMGYIFYPRKLR
• Molecular Formula: C101H152N28O22S2
• Molecular Weight: 2174.58 g/mol
• Purity: >98% (HPLC)
• Appearance: White lyophilized powder
• Quantity: 10mg per vial

Storage

• Store lyophilized peptide at -20°C for long-term storage (up to 36 months).
• For short-term storage (up to 4 weeks), refrigerate at 2-8°C.
• After reconstitution, store at 2-8°C and use within 30 days.
• Avoid repeated freeze-thaw cycles.
• Protect from light and moisture at all times.

Certificate of Analysis

Every batch of MOTS-c sold by Pepspan undergoes rigorous third-party testing. Our Certificate of Analysis (COA) includes HPLC purity analysis, mass spectrometry confirmation, amino acid analysis, endotoxin testing, and sterility verification. COA documentation is available upon request for any batch number.

Current Batch: Pending first shipment

Every batch of MOTS-c 10mg sold by Pepspan is independently tested by Janoshik Analytical (Prague, Czech Republic). HPLC purity analysis, mass spectrometry, and amino acid sequencing are performed for each shipment. Reports are batch-specific — not generic.

Research Disclaimer

This product is intended for laboratory research use only. It is not a drug, food, cosmetic, or dietary supplement. MOTS-c is not approved for human or veterinary use by any regulatory agency. It must not be administered to humans or animals outside of approved clinical trials. By purchasing this product, you confirm that you are a qualified researcher and that this product will be used exclusively for legitimate scientific research purposes. Pepspan assumes no liability for any misuse of this product.