Quick answer
Kisspeptin-10 is the C-terminal decapeptide of kisspeptin, sequence Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2, the shortest fragment reported to retain full activity at its receptor. It is used in laboratories as a reference agonist of the KISS1 receptor (GPR54) in structure-activity and signalling studies — cell and animal models, not claims about human use. Pepspan will supply a 10 mg vial at €69.90, shipped from Spain, with every lot independently tested; coming soon — join the waitlist with Notify me. Updated 30 September 2026.
What Kisspeptin-10 Is
Kisspeptin-10 is the C-terminal decapeptide of kisspeptin, corresponding to the human sequence Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 (residues 45-54 of kisspeptin-54, also called metastin). It is the shortest fragment of the KISS1 gene product reported to retain full activity at its receptor.
Its molecular formula is C63H83N17O14, with a molecular weight of approximately 1,302.4 g/mol. The C-terminal Arg-Phe-NH2 motif places kisspeptin in the RF-amide peptide family. It is supplied as a white lyophilized powder — a reference material for laboratory research, not a drug, food, cosmetic or dietary supplement.
| Property | Kisspeptin-10 |
|---|---|
| Sequence | Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 |
| Length | 10 amino acids (decapeptide), C-terminal amidation |
| Molecular formula | C63H83N17O14 |
| Molecular weight | ≈1,302.4 g/mol |
| Receptor target | KISS1 receptor (KISS1R / GPR54) |
| Peptide family | RF-amide |
What Research Looks At: Receptor Pharmacology
Kisspeptin-10 acts as an agonist of the KISS1 receptor (KISS1R), also known as GPR54, a G-protein-coupled receptor. Structure-activity studies identify Phe6, Arg9 and the amidated C-terminal Phe10 as critical for receptor binding and activation.
Kisspeptin-10 is widely used in laboratories as a reference agonist in KISS1 receptor pharmacology. Published research in cell and animal models examines receptor binding and its Gq/11-coupled phospholipase C signalling with downstream calcium mobilisation, together with structure-activity relationships of kisspeptin analogues. These findings describe receptor-level pharmacology in research settings; they are not claims about human use or about any specific product.
How Kisspeptin-10 Differs from the Full-Length Peptide
Kisspeptin-10 is the shortest kisspeptin form, not the full-length peptide. The KISS1 gene encodes a longer precursor that is processed into kisspeptin-54 (also called metastin) and shorter fragments, including kisspeptin-14, kisspeptin-13 and kisspeptin-10. All of these forms share the same C-terminal decapeptide sequence and RF-amide motif required for receptor activation, and the shortest, kisspeptin-10, is widely used as a reference agonist in receptor-binding and signalling studies.
Researchers choose the fragment length to suit the assay: the decapeptide is often chosen for structure-activity and receptor-binding work because it is the minimal sequence reported to retain full activity. Because all fragments converge on the same C-terminal motif, published structure-activity data on kisspeptin-10 also informs the interpretation of studies that use the longer forms.
What to Check When Sourcing Kisspeptin-10 in the EU
Before ordering a Kisspeptin-10 vial from an EU shop, a few things are worth checking on the product page itself:
- A per-lot report from an independent laboratory. A report tied to the specific production lot on the vial, issued by an independent laboratory, with a way to verify it.
- A working verification link. Ideally a link that opens the result directly on the laboratory's own site, not only a PDF or image hosted by the seller.
- Content per vial against the label claim. A purity percentage and a measured content in milligrams per vial are two different figures; check which one, or both, the report gives.
- Shipping inside the EU and the seller's returns policy. An EU-based shipping point usually avoids customs processing; check the return window for unopened products.
At Pepspan, the first lot of Kisspeptin-10 will be analysed on arrival by an independent laboratory, with the report and a verification link published on its public lot page; every later lot is analysed and published the same way. Orders ship tracked from Spain: after dispatch, delivery typically takes 1-3 business days within Spain, 1-2 to Portugal, 3-5 to Germany and Italy, up to 5 to the Netherlands, and usually 2-5 business days across the rest of the EU. EU shipping is free on orders from €50 (otherwise €6), and unopened products can be returned within 14 days — see the shipping policy and refund policy.
Availability at Pepspan
Kisspeptin-10 is not in stock yet at Pepspan. The product page lists a 10 mg lyophilized vial at €69.90, with a purity specification of ≥98% by HPLC; leave your email with the Notify me button to be told as soon as the first lot is in stock. Its independent report will be published on the lot page.
Once available, the lot report will also appear on the purity reports page alongside Pepspan's other published results, and it can be checked as described in the COA verification guide.
Frequently asked questions
What is Kisspeptin-10?
Kisspeptin-10 is the C-terminal decapeptide of kisspeptin, human sequence Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2. It is used in laboratories as an agonist reference compound for the KISS1 receptor (GPR54).
What receptor does Kisspeptin-10 act on?
Kisspeptin-10 acts as an agonist at the KISS1 receptor (KISS1R), also known as GPR54, a G-protein-coupled receptor. Structure-activity studies identify Phe6, together with Arg9 and the amidated Phe10 of its C-terminal Arg-Phe-NH2 (RF-amide) motif, as critical for receptor binding and activation.
Why is Kisspeptin-10 used instead of the full-length peptide?
Kisspeptin-10 is the shortest fragment of the KISS1 gene product reported to retain full activity at its receptor, which makes it a convenient reference compound for structure-activity and receptor-binding studies compared with longer fragments such as kisspeptin-54.
What research areas study Kisspeptin-10?
Published research on Kisspeptin-10 covers KISS1 receptor pharmacology in cell and animal models: receptor binding, Gq/11-coupled phospholipase C and calcium signalling, and structure-activity studies of kisspeptin analogues.
What is the molecular weight of Kisspeptin-10?
Kisspeptin-10 has the molecular formula C63H83N17O14 and a molecular weight of approximately 1,302.4 g/mol.
When will Kisspeptin-10 be available at Pepspan?
Kisspeptin-10 is coming soon. Use the Notify me button on the product page to receive an email as soon as the first lot is in stock; its independent lab report will be published on the lot page.
Where can I buy Kisspeptin-10 in Europe?
Pepspan will supply Kisspeptin-10 as a 10 mg lyophilized vial at €69.90, shipped tracked from Spain; EU shipping is free on orders from €50 (otherwise €6). It is not in stock yet: join the waitlist with the Notify me button. Rules on buying and handling research peptides differ by country; check your local regulations. Research use only.
Research Use Only: all products mentioned are intended exclusively for laboratory research and are not for human or veterinary use. Information about other suppliers reflects their public websites as checked on the date stated and may change.