Quick answer
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule, membrane-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that methylates nicotinamide using S-adenosylmethionine (SAM). Because nicotinamide feeds the NAD+ salvage pathway, NNMT sits at the junction of NAD+ metabolism and cellular methylation — studied in cell and animal models, not claims about human use. Pepspan will supply a 50 mg vial at €89.90, shipped from Spain, with every lot independently tested; coming soon — join the waitlist with Notify me. Updated 30 September 2026.
What 5-Amino-1MQ Is
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule research compound — not a peptide — developed as a selective, membrane-permeable inhibitor of nicotinamide N-methyltransferase (NNMT). NNMT is a cytosolic enzyme that transfers a methyl group from S-adenosylmethionine (SAM) to nicotinamide, producing 1-methylnicotinamide.
As a quaternary quinolinium cation, its molecular formula is C10H11N2+ with a molecular weight of 159.21 g/mol (286.11 g/mol as the iodide salt). It is supplied as a lyophilized solid — a reference material for laboratory research, not a drug, food, cosmetic or dietary supplement.
| Property | 5-Amino-1MQ |
|---|---|
| Compound type | Small molecule (quaternary quinolinium), not a peptide |
| Target | Nicotinamide N-methyltransferase (NNMT) inhibitor |
| Molecular formula | C10H11N2+ (cation); C10H11IN2 as the iodide salt |
| Molecular weight | 159.21 g/mol (cation); 286.11 g/mol (iodide salt) |
| Related pathway | NAD+ salvage pathway (via nicotinamide) |
What Research Looks At: NNMT Inhibition
Because nicotinamide is a precursor in the NAD+ salvage pathway and SAM is the cell's main methyl donor, NNMT sits at the junction of NAD+ metabolism and cellular methylation.
In published work from the University of Texas Medical Branch (Neelakantan et al., Biochemical Pharmacology, 2018), 5-amino-1MQ lowered 1-methylnicotinamide and raised intracellular NAD+ and SAM levels in cultured adipocytes. A later study by the same group (2019) examined NNMT inhibition with 5-amino-1MQ in models of aged skeletal-muscle regeneration. These are preclinical findings in cell and animal models; they have not been demonstrated in humans and are not claims about any specific product.
5-Amino-1MQ and NAD+ Metabolism Research
5-Amino-1MQ's connection to NAD+ metabolism comes from its enzymatic target: NNMT consumes nicotinamide, the same precursor molecule used in the NAD+ salvage pathway. In cultured adipocytes, inhibiting NNMT with 5-amino-1MQ has been associated with higher intracellular NAD+ and SAM levels, which is why the compound is studied alongside NAD+ itself in cellular metabolism research — see also the NAD+ research guide.
NAD+ and 5-Amino-1MQ act through different mechanisms — NAD+ is the coenzyme itself, while 5-Amino-1MQ inhibits NNMT, an enzyme that consumes nicotinamide, the precursor the salvage pathway uses to regenerate NAD+ — but both appear in the same area of metabolic-pathway research literature.
What to Check When Sourcing 5-Amino-1MQ in the EU
Before ordering a 5-Amino-1MQ vial from an EU shop, a few things are worth checking on the product page itself:
- A per-lot report from an independent laboratory. A report tied to the specific production lot on the vial, issued by an independent laboratory, with a way to verify it.
- A working verification link. Ideally a link that opens the result directly on the laboratory's own site, not only a PDF or image hosted by the seller.
- Content per vial against the label claim. A purity percentage and a measured content in milligrams per vial are two different figures; check which one, or both, the report gives, and which salt form the certificate refers to.
- Shipping inside the EU and the seller's returns policy. An EU-based shipping point usually avoids customs processing; check the return window for unopened products.
At Pepspan, the first lot of 5-Amino-1MQ will be analysed on arrival by an independent laboratory, with the report and a verification link published on its public lot page; every later lot is analysed and published the same way. Orders ship tracked from Spain: after dispatch, delivery typically takes 1-3 business days within Spain, 1-2 to Portugal, 3-5 to Germany and Italy, up to 5 to the Netherlands, and usually 2-5 business days across the rest of the EU. EU shipping is free on orders from €50 (otherwise €6), and unopened products can be returned within 14 days — see the shipping policy and refund policy.
Availability at Pepspan
5-Amino-1MQ is not in stock yet at Pepspan. The product page lists a 50 mg vial at €89.90, with a purity specification of ≥98% by HPLC; leave your email with the Notify me button to be told as soon as the first lot is in stock. Its independent report will be published on the lot page.
Once available, the lot report will also appear on the purity reports page alongside Pepspan's other published results, and it can be checked as described in the COA verification guide.
Frequently asked questions
What is 5-Amino-1MQ?
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), the enzyme that methylates nicotinamide using S-adenosylmethionine. It was developed as a selective, membrane-permeable NNMT inhibitor for metabolic-pathway research.
Is 5-Amino-1MQ a peptide?
No. 5-Amino-1MQ is a small quaternary quinolinium molecule, not a peptide. It is supplied in a vial like the peptides in Pepspan's catalogue, but its chemistry, size and handling are those of a small-molecule compound.
How does 5-Amino-1MQ relate to NAD+?
NNMT consumes nicotinamide, a precursor in the NAD+ salvage pathway, and S-adenosylmethionine, the cell's main methyl donor. In cultured adipocytes, inhibiting NNMT with 5-amino-1MQ has been associated with higher intracellular NAD+ and SAM levels, which is why the compound is studied alongside NAD+ metabolism research.
What research cites 5-Amino-1MQ?
The main published work comes from the University of Texas Medical Branch: a 2018 study in Biochemical Pharmacology (cell and mouse models) and a 2019 study on NNMT inhibition in cell and mouse models of aged skeletal-muscle regeneration. These are preclinical findings, not demonstrated in humans.
What is the molecular weight of 5-Amino-1MQ?
The cation has the molecular formula C10H11N2+ and a molecular weight of 159.21 g/mol. As the iodide salt, the formula is C10H11IN2 with a molecular weight of 286.11 g/mol.
When will 5-Amino-1MQ be available at Pepspan?
5-Amino-1MQ is coming soon. Use the Notify me button on the product page to receive an email as soon as the first lot is in stock; its independent lab report will be published on the lot page.
Where can I buy 5-Amino-1MQ in Europe?
Pepspan will supply 5-Amino-1MQ as a 50 mg vial at €89.90, shipped tracked from Spain; EU shipping is free on orders from €50 (otherwise €6). It is not in stock yet: join the waitlist with the Notify me button. Rules on buying and handling research compounds differ by country; check your local regulations. Research use only.
Research Use Only: all products mentioned are intended exclusively for laboratory research and are not for human or veterinary use. Information about other suppliers reflects their public websites as checked on the date stated and may change.